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  • Title: Comparison of percutaneous anaesthesia for venous cannulation after topical application of either amethocaine or EMLA cream.
    Author: Molodecka J, Stenhouse C, Jones JM, Tomlinson A.
    Journal: Br J Anaesth; 1994 Feb; 72(2):174-6. PubMed ID: 8110569.
    Abstract:
    We have compared, in a double-blind study, the efficacy of topical amethocaine cream 1 g (5% w/w) in alleviating the pain of venous cannulation with that of 5% EMLA cream 2.5 g. One hundred and twenty unpremedicated female patients undergoing minor gynaecological surgery, were allocated randomly to one of four groups: 5% EMLA cream 2.5 g for 30 min: 5% EMLA cream 2.5 g for 60 min; amethocaine cream 1 g (5% w/w) for 30 min; amethocaine cream 1 g (5% w/w) for 60 min. After removal of the cream, venous cannulation was performed with an 18-gauge cannula. Patients assessed the pain experienced using a 100-mm visual analogue score and four-point rank score. In addition, a blinded observer assessed the patient's response to venous cannulation using a four-point rank score. Good analgesia was obtained in all groups and there was no statistically significant difference in pain scores between the groups.
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