These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of neuromedin U-8 on the rat pituitary-adrenocortical axis.
    Author: Malendowicz LK, Nussdorfer GG, Nowak KW, Mazzocchi G.
    Journal: In Vivo; 1993; 7(5):419-22. PubMed ID: 8110984.
    Abstract:
    A single subcutaneous injection of 6 micrograms/100 g body wt. of neuromedin U-8 (NMU8) resulted in a transient increase in ACTH blood concentration (between 3 and 12 h) and a sustained (24 h) elevation of plasma corticosterone (B) concentration (PBC). After a 2-day subcutaneous administration of NMU8 (2 or 6 micrograms/100 g/day) blood ACTH level remained unchanged, but PBC was notably raised. Adrenal glands were atrophic, due to a marked loss of parenchymal cells, but in spite of this their basal in vitro output of B did not differ from that of control glands. These findings indicate that NMU8 stimulates pituitary-adrenocortical axis in rats. Furthermore, they suggest that, in addition to the enhancement in ACTH release, other mechanism(s) must be involved in the adrenocortical secretagogue effect of NMU8.
    [Abstract] [Full Text] [Related] [New Search]