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  • Title: [Prevention of toxicity of cyclosporine A on rat pancreatic islet beta-cells by Ligustrazine].
    Author: Gu MJ, Liu ZM.
    Journal: Zhongguo Zhong Xi Yi Jie He Za Zhi; 1993 Sep; 13(9):542-3, 517. PubMed ID: 8111213.
    Abstract:
    The toxic effect of cyclosporine A (CsA) on pancreatic islet beta-cells and the preventive effect of ligustrazine (LIG) on CsA-associated beta-cell toxicity in SD rats were investigated. The oral administration of CsA 50 mg/kg/day for ten days caused hyperglycaemia and lowering of plasma and pancreatic insulin levels that were prevented and/or minimized by the combined intra-peritoneal administration of LIG 50 mg/kg/day. An increase of urinary thromboxane B2 (TXB2) and urinary TXB2/6-keto-prostaglandin F1 alpha (6-k-PGF1 alpha) ratio in CsA-treated rats could also be prevented and/or minimized by the administration of LIG. The results suggested that the preventive effect of LIG on CsA-associated islet beta-cell toxicity was relevant to the improvement of prostacyclin-thromboxane A2 imbalance.
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