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  • Title: Brofaromine in elderly major depressed patients--a comparative trial versus imipramine.
    Author: Möller HJ, Volz HP.
    Journal: Eur Neuropsychopharmacol; 1993 Dec; 3(4):501-10. PubMed ID: 8111223.
    Abstract:
    In an 8-week controlled double-blind clinical trial with a total of 189 elderly patients brofaromine showed comparable efficacy to imipramine (Hamilton Depression Scale, von Zerssen self-rating scale, global evaluation). The numbers of adverse events were the same in both groups, but the spectrum differed distinctly. In the global evaluation of tolerability, there was an advantage for brofaromine. Mean daily doses were 85 mg/day in the brofaromine group and 87 mg/day in the imipramine group. Long-term efficacy and tolerability also proved to be good in the open follow-up of the patients treated with brofaromine.
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