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  • Title: [Morphine does not prevent the development of a pain syndrome in rats induced by transection of the sciatic nerve].
    Author: Kukushkin ML, Smirnova VS, Gorizontova MP, Zinkevich VA, Mironova IV.
    Journal: Eksp Klin Farmakol; 1993; 56(6):11-3. PubMed ID: 8111285.
    Abstract:
    The effects of morphine on the development of the neurogenic pain syndrome were studied in rats after sciatic nerve dissection. Morphine was injected subcutaneously in doses of 0.1, 1.0, and 5.0 mg/kg every day, starting on the first day after dissection. It has been shown that despite the fact that morphine initially arrests the development of the pain syndrome, then it intensifies its course. Possible mechanisms responsible for the inefficacy of morphine in neurogenic pain syndromes are discussed.
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