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  • Title: [The effect of D-glucuronic acid on the regenerative processes of granulomonocytopoiesis in cytostatic-induced myelodepression].
    Author: Gol'dberg ED, Dygaĭ AM, Karpova GV, Simanina EV, Khlusov IA, Shakhov VP, Agafonov VI.
    Journal: Eksp Klin Farmakol; 1993; 56(6):25-8. PubMed ID: 8111290.
    Abstract:
    Whether cytostatic-induced disorders of the blood system can be corrected with D-glucuronic acid has been studied in murine experiments. D-glucuronic acid has been demonstrated to selectively stimulate the processes of bone marrow granulomonocytopoiesis both in intact animals and in rats with bone marrow hypoplasia induced by cyclophosphanum. During D-glucuronic acid administration, stimulation of hemopoietic regenerative processes is followed by the development of granulocyte lineage hyperplasia in bone marrow, the rapid restoration of blood polymorphonuclear leukocyte and monocyte counts and the development of neutrophilia and monocytosis.
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