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  • Title: Inhibition of salt-induced gustatory responses in the frog (Rana catesbeiana) by 5'-GMP.
    Author: Miyamoto T, Okada Y, Sato T.
    Journal: Brain Res; 1993 Dec 03; 629(2):345-8. PubMed ID: 8111639.
    Abstract:
    Millimolar concentration of sodium 5'-guanylate (5'-GMP), a 'umami' substance, inhibited salt-induced gustatory neural responses, particularly tonic components, of the bullfrog when the tongue was adapted to a low salt (5 mM NaCl) solution but not when adapted to normal saline that contained 115 mM NaCl. The result suggests that 5'-GMP is a modulator of adaptation process in salt response in the bullfrog taste system.
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