These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Protective effect of monoclonal antibody of tumor necrosis factor-alpha for vital organs in a model suffering from intestinal ischemia and reperfusion injury].
    Author: Yao YM.
    Journal: Zhonghua Wai Ke Za Zhi; 1993 Aug; 31(8):497-500. PubMed ID: 8112180.
    Abstract:
    Monoclonal antibody to tumor necrosis factor-alpha (TNFa-MAb), z8, was used to explore protective effect on multiple organ dysfunction caused by intestinal ischemia and reperfusion in rats. Systemic plasma TNF level rose rapidly after release of the clamp, on superior mesenteric artery, and reached peak level 2 hours later. Endotoxemia and bacteremia were associated with systemic TNF level, and portal endotoxin concentration increased significantly before elevation of TNF activity. Pretreatment with anti-TNFa antibody markedly attenuated the increase of TNF level and provided protection from the development of hypotension, vital organ dysfunction, and metabolic acidosis. As a result the survival rate in treatment group increased by 35.7%. Our results demonstrated that TNF might play an important role in mediating the pathophysiologic changes in the pathogenesis of multiple organ damage in this intestinal ischemia-reperfusion injury model, and monoclonal antibody to TNF offered significant protection against multiple organ dysfunction or failure after severe trauma.
    [Abstract] [Full Text] [Related] [New Search]