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  • Title: A comparative assessment of amlodipine and felodipine ER: pharmacokinetic and pharmacodynamic indices.
    Author: Bainbridge AD, Herlihy O, Meredith PA, Elliott HL.
    Journal: Eur J Clin Pharmacol; 1993; 45(5):425-30. PubMed ID: 8112371.
    Abstract:
    This study investigated potential therapeutic differences between Amlodipine 5 mg and Felodipine ER 10 mg in 12 normotensive/borderline hypertensive subjects by comparison of the plasma drug concentration-time profiles and the blood pressure and heart rate responses. There was significantly less trough-to-peak variability in plasma drug concentrations with amlodipine with a ratio of 67%, compared to 37% for felodipine. Correspondingly there was less variability with amlodipine in the blood pressure reductions across the dosage interval. Overall, amlodipine displayed a more consistent hypotensive effect across 24 hours and lower blood pressure values at trough, i.e. 24 hours post-dose.
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