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  • Title: The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1.
    Author: Martin D, Thompson MA, Nadler JV.
    Journal: Eur J Pharmacol; 1993 Dec 21; 250(3):473-6. PubMed ID: 8112408.
    Abstract:
    Riluzole is believed to exert its anticonvulsant and neuroprotective actions by reducing glutamate release. This study demonstrated that 10-30 microM riluzole reduces the K(+)-evoked release of glutamate and aspartate from slices of hippocampal area CA1. Only higher concentrations reduced gamma-aminobutyrate (GABA) release. These actions of riluzole were not occluded by tetrodotoxin. Riluzole did not diminish the ability of glutamate analogues to depolarize CA1 pyramidal cells, as determined from grease-gap recordings. Therefore the anticonvulsant and neuroprotective actions of riluzole in the hippocampus may be at least partly explained by its ability to inhibit glutamate/aspartate release from synaptic terminals.
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