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  • Title: Effects of organic and inorganic Ca(2+)-antagonists on acetylcholine-induced contraction in molluscan (Mytilus edulis) smooth muscle.
    Author: Miyahara Y, Kizawa Y, Sano M, Murakami H.
    Journal: Gen Pharmacol; 1993 Nov; 24(6):1419-23. PubMed ID: 8112515.
    Abstract:
    1. Effect of Ca(2+)-antagonist on the contractile response to acetylcholine (ACh) in molluscan (Mytilus edulis) smooth muscle was investigated. 2. ACh-induced contraction was remarkably reduced by exposure to Ca(2+)-deprived medium. 3. The organic Ca(2+)-blockers, verapamil, diltiazem and nicardipine, reduced the concentration-response curve for ACh in a concentration-dependent manner. 4. The inorganic Ca(2+)-blockers, MnCl2, NiCl2, CoCl2 and CdCl2, also reduced the concentration-response curve for ACh concentration-dependently. 5. ACh significantly increased the amounts of inositol 1,4,5-trisphosphate (IP3) in the ABRM. 6. ACh-induced contraction in the ABRM might therefore be mediated through an influx of extracellular Ca2+ and Ca(2+)-release from IP3 sensitive intracellular pools.
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