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  • Title: Effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline.
    Author: Sangeeta, Raina RK, Bano G.
    Journal: Indian J Physiol Pharmacol; 1993 Oct; 37(4):303-7. PubMed ID: 8112806.
    Abstract:
    In a single dose crossover study, the effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline was investigated. Compared to fasting subjects, carbohydrate and fat rich diet caused an enhancement of absorption half life and a lower Cmax with a delayed tmax and elimination of the bronchodilator. Protein coadministration decreased AUCO-OC of the drug without significantly altering its absorption or elimination kinetics.
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