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  • Title: Interval effect of beta-irradiation and subsequent 4-nitroquinoline 1-oxide painting on skin tumor induction in mice.
    Author: Hoshino H, Tanooka H.
    Journal: Cancer Res; 1975 Dec; 35(12):3663-6. PubMed ID: 811353.
    Abstract:
    Skin tumors were produced in female ICR mice by 90Sr-90Y beta-irradiation and subsequent 4-nitroquinoline 1-oxide painting. The doses were chosen so as to produce no tumors with a single agent alone; the interval between two treatments ranged from 11 to 408 days. The tumor induction rate was found to be at almost the same level (average, 12.4%) for each interval. The results indicate the persistence of the latent carcinogenic alterations in the beta-irradiated mouse skin.
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