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  • Title: Effect of topical interferon-alpha 2b on corneal haze after excimer laser photorefractive keratectomy in rabbits.
    Author: Morlet N, Gillies MC, Crouch R, Maloof A.
    Journal: Refract Corneal Surg; 1993; 9(6):443-51. PubMed ID: 8117643.
    Abstract:
    BACKGROUND: Anterior corneal stromal keratocytes are activated by excimer laser photorefractive keratectomy resulting in haze with healing of the ablated area. In some eyes, this causes a visible haze or scar on the cornea, and an unpredictable regression of the myopic correction following refractive ablations. METHODS: Following a 6.00-diopter excimer laser photorefractive keratectomy to both eyes, 16 rabbits were treated for 5 weeks with interferon-alpha 2b drops four times a day to one eye only. Eight of these rabbits were treated with dexamethasone drops four times a day to both eyes. Using a standard grading scale for haze, the corneas were examined and the haze graded weekly. RESULTS: The observed corneal haze was significantly reduced in the treated eyes by the application of topical interferon-alpha 2b drops (p = .004), and topical dexamethasone drops (p < .001). Topical dexamethasone also produced less haze in combination with interferon-alpha 2b than when used alone (p = .035). There was continuing resolution of the corneal haze in those rabbits observed for 7 weeks after the cessation of the drops. Topical interferon-alpha therapy was not toxic to the rabbit eye and was not associated with delayed reepithelialization after the laser procedure. CONCLUSION: Topical interferon-alpha 2b appears to reduce the corneal haze produced by excimer laser photorefractive keratectomy in rabbits.
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