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  • Title: [The production by bone marrow cells of humoral factors in extreme exposures of different origins].
    Author: Gol'dberg ED, Dygaĭ AM, Khlusov IA, Bogdashin IV, Shakhov VP, Agafonov VI, Zhdanov VV, Gumilevskiĭ BIu, Sherstoboev EIu.
    Journal: Biull Eksp Biol Med; 1993 Sep; 116(9):244-6. PubMed ID: 8117988.
    Abstract:
    The intensification of cytokine-producing activity by mouse bone marrow cells forming the hemopoiesis-inducing microenvironment (HIM) was demonstrated to be an obligatory component of adaptation processes developing in the body under the influence of different extreme factors (immobilization, inflammation, cytostatics, irradiation). As a rule, the first stress reaction of adhesive and nonadhesive cells consists in interleukin-1 and interleukin-3 secretion with following erythropoietic and colony-stimulating activity induction. For all this, the levels and periods of production of hemopoiesis humoral regulators are comparable under hemopoiesis-stimulating or -suppressing influences. Finally Activation of HIM functional properties expresses the interaction of central and local regulating systems, which favours the formation of an optimal response of the blood system to stress.
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