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  • Title: Repression of in vitro transcription of the Escherichia coli fnr and nar X genes by FNR protein.
    Author: Takahashi K, Hattori T, Nakanishi T, Nohno T, Fujita N, Ishihama A, Taniguchi S.
    Journal: FEBS Lett; 1994 Feb 28; 340(1-2):59-64. PubMed ID: 8119409.
    Abstract:
    In facultative anaerobes, the anaerobic expression of respiratory genes is regulated by a transcriptional activator, FNR. Transcription in vitro of the E. coli fnr gene was repressed by its product, FNR. The transcription of the E. coli narX gene encoding the nitrate sensor protein was likewise repressed. DNA truncation experiments for fnr and narX genes indicated that multiple anaero-boxes in each promoter region are essential for repression by the FNR protein, but they also suggest that factor-independent upstream activation signals are operating with these promoters.
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