These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Intracerebroventricular treatment with vasopressin V1-receptor antagonist inhibits centrally-mediated pressor response to clonidine in conscious rats.
    Author: Nakamura S, Kawasaki H, Takasaki K.
    Journal: Jpn J Pharmacol; 1993 Dec; 63(4):447-53. PubMed ID: 8121079.
    Abstract:
    The effect of intracerebroventricular (i.c.v.) treatment with a vasopressin (AVP) V1-receptor antagonist on the pressor response to i.c.v. injection of clonidine was investigated in conscious rats with chronic i.c.v. guide cannulas and an arterial catheter. In conscious rats, i.c.v.-injected clonidine (5 and 10 micrograms) dose-dependently produced a pressor response with a decrease in heart rate. No significant depressor response was induced by clonidine. The i.c.v. pretreatment with an AVP V1-receptor antagonist ([d(CH2)5-Tyr(Me)]-AVP) at 0.5-2.5 micrograms dose-dependently inhibited the pressor response to 10 micrograms of i.c.v.-injected clonidine, while systemic (i.v.) pretreatment with the antagonist (2.5 micrograms) had no effect. In pentobarbital-anesthetized rats, 10 micrograms of i.c.v.-injected clonidine caused a marked depressor response associated with bradycardia. However, i.c.v. pretreatment with the antagonist (2.5 micrograms) did not affect cardiovascular responses to i.c.v.-injected clonidine. These results suggest that endogenous AVP in the brain is involved in the mechanisms underlying the pressor response to i.c.v.-injected clonidine in conscious rats.
    [Abstract] [Full Text] [Related] [New Search]