These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Characterization and differentiation of peripheral-type benzodiazepine receptors in rat and human prostate.
    Author: Camins A, Sureda FX, Pubill D, Camarasa J, Escubedo E.
    Journal: Life Sci; 1994; 54(12):759-67. PubMed ID: 8121239.
    Abstract:
    We have characterized the presence of peripheral-type benzodiazepine receptor in rat and human prostate. [3H] PK 11195, a putative antagonist, showed a greater affinity for this receptor in rat prostate (KD = 1.71 +/- 0.18 nM) than in human (KD = 15.23 +/- 1.20 nM). In human, the peripheral-type benzodiazepine receptor density (Bmax = 13,575 +/- 1,929 fmols/mg) is double that in rat (Bmax = 6,345 +/- 314 fmols/mg). [3H] Ro 5-4864, an agonist, showed a low affinity (KD = 188.38 +/- 16.46 nM) for human peripheral-type benzodiazepine receptor subtype. We did not detect any difference between the population of this receptor in control human prostate and that in hyperplastic specimens. In rat, bound [3H] PK 11195 was partially inhibited by specific ligands of mitochondrial ADP/ATP carrier. This characteristic does not occur in human prostate. A common trait of both rat and human prostate peripheral-type benzodiazepine receptors is the competitive displacement of bound [3H] PK 11195 by nitrendipine and the blockers of the adenosine uptake system.
    [Abstract] [Full Text] [Related] [New Search]