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  • Title: Lipoprotein and lecithin: cholesterol acyltransferase changes in galactosamine-induced rat liver injury.
    Author: Sabesin SM, Kuiken LB, Ragland JB.
    Journal: Science; 1975 Dec 26; 190(4221):1302-4. PubMed ID: 812181.
    Abstract:
    Abnormal lipoproteins and drcreased lecithin: cholesterol acyltransferase activity are found in rat plasma following intraperitoneal injection of D-galactosamine. The changes observed, including absence of alpha-lipoprotein and the presence of lipoproteins rich in phospholipid and unesterified cholesterol but deficient in cholesteryl esters, are remarkably similar to changes found in human pathologic states of lecithin: cholesterol acyltransferase deficiency. When examined by electron microscopy, all of the major lipoprotein classes isolated by ultracentrifugation showed morphological abnormalities including the formation of rouleaus consisting of disk-shaped particles.
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