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  • Title: Hepatobiliary changes in Nigerians with sickle cell anaemia.
    Author: Aken'ova YA, Olasode BJ, Ogunbiyi JO, Thomas JO.
    Journal: Ann Trop Med Parasitol; 1993 Dec; 87(6):603-6. PubMed ID: 8122922.
    Abstract:
    The histology of a liver specimen from the autopsy of each of 58 sickle cell anaemia patients aged 3-45 years was examined. Sinusoidal distension (present in all specimens), haemosiderosis and erythrophagocytosis (56), portal triaditis (47), cholestasis (24), focal necrosis and fibrosis (23), and extra-medullary erythropoiesis (3) were observed. The livers from the older patients (30-45 years) showed severe haemosiderosis, chronic inflammation, pigment stones and fatty change.
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