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  • Title: Partial sequence analysis of the hepatitis C viral genome in Singapore patients.
    Author: Lee AS, Ng KY, Chee MK, Vathsala A, Choong HL, Ng HS, Oon CJ.
    Journal: Biochem Biophys Res Commun; 1994 Feb 28; 199(1):37-40. PubMed ID: 8123037.
    Abstract:
    The distribution of hepatitis C viral (HCV) genotypes in Singapore has not been previously determined. We studied the sera of 40 Singapore patients which were PCR-positive for HCV. The HCV genotypes were determined by direct sequencing of amplified sequences of the 5' non-coding region, after reverse transcription. Of the 40 samples, 35/40 (87.5%) were of HCV type 1, 2/40 (5.0%) were of type 2 and 3/40 (7.5%) were of type 3. The most common HCV genotype in this study was the type 1 genotype. Our results confirm the wide geographical distribution of HCV genotypes.
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