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  • Title: [Adaptation to stress can enhance animal resistance to sublethal hypoxia to a greater extent than adaptation to hypoxia].
    Author: Meerson FZ, Pozharov VP, Miniaĭlenko TD, Golubeva LIu.
    Journal: Biull Eksp Biol Med; 1993 Dec; 116(12):574-7. PubMed ID: 8123804.
    Abstract:
    Wistar male rats were adapted to intermittent hypoxia in an altitude chamber (group 1) and to short-term immobilization stress (group 2). The animals of both series and control ones were exposed to severe hypoxic hypoxia in acute experiment: they were anesthetized and inhaled a gas mixture which contained 6% O2. In the first two hours of the experiment the death rate was 65% in control, 10% in adaptation to stress, and 29% in adaptation to hypoxia. Principal parameters of respiration, circulation, and basic-acid equilibrium were monitored during the experiment. They allowed us to establish that both the variants of adaptation increased the tissue oxygen consumption; furthermore, adaptation to hypoxia preserved a higher level of oxygen consumption than adaptation to stress. Despite this, in adaptation to stress the death rate was threefold higher than in adaptation to hypoxia. This result was explained by the accumulation of heat shock proteins in cells during adaptation to stress and the resultant development of a phenomenon of adaptive stabilization of structures (PhASS). In adaptation to hypoxia the PhASS did not develop.
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