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  • Title: Evaluation of three assays for the determination of serum total sialic acid.
    Author: Crook M, Haq M, Tutt P.
    Journal: Clin Biochem; 1993 Dec; 26(6):449-54. PubMed ID: 8124859.
    Abstract:
    There is increasing clinical interest in the measurement of serum total sialic acid (TSA). There are a number of methods available but with little data suggesting the preferred technique. We evaluated three serum sialic acid assays: the Warren assay, the Svennerholm assay, and a commercially available enzymatic method. The analytical performances of the three assays were similar, except that the enzymatic assay had a greater analytical range than the other assays and better precision at low and high serum sialic acid concentrations. The enzymatic assay was readily automated for use on a Cobas Bio analyser but was substantially more expensive than the other two methods.
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