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  • Title: Structure and expression of the gene for the prothoracicotropic hormone of the silkmoth Bombyx mori.
    Author: Adachi-Yamada T, Iwami M, Kataoka H, Suzuki A, Ishizaki H.
    Journal: Eur J Biochem; 1994 Mar 01; 220(2):633-43. PubMed ID: 8125124.
    Abstract:
    We cloned and characterized two allelic variants of the gene for the Bombyx mori prothoracicotropic hormone (PTTH), a homodimeric 30-kDa brain secretory protein. These PTTH genes contain five exons that encode a precursor protein consisting of 224 amino acid residues whose C-terminal 109 residues represent the PTTH subunit. The Bombyx haploid genome contains a single copy of the PTTH gene. The major site of PTTH expression is the brain but expression at a very low level occurs in the gut. One Bombyx brain at day 0 of the fifth larval instar contained 2.4-2.8 pg PTTH mRNA, and this amount did not change markedly during larval-pupal development.
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