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  • Title: Genetic relationship between mouse adenovirus-2 (strain K87) and human adenovirus-2.
    Author: Jacques C, D'Amours B, Hamelin C.
    Journal: FEMS Microbiol Lett; 1994 Jan 01; 115(1):7-11. PubMed ID: 8125249.
    Abstract:
    The DNA of mouse adenovirus strain K87 (MAd-2) was cloned and mapped with restriction endonucleases BglII, ClaI, EcoRI, HindIII and SphI. Large differences were found between the MAd-2 and MAd-1 (strain FL) DNA molecules in terms of number and location of restriction sites. The MAd-2 genome also appeared as larger in size than the MAd-1 genome (34.72 kb vs. 30.14 kb). Our results confirm the existence of two distinct adenovirus species in the mouse. Hybridization experiments, on the other hand, indicate that both MAd-1 and MAd-2 are genetically related to human adenovirus type 2 (HAd-2). Overlapping regions of DNA homology are located in genes coding for HAd-2 structural components which could explain serological relationships observed between the human and the murine adenoviruses.
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