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  • Title: [The isoenzyme identification of Leishmania isolates taken from greater gerbils, sandflies and human patients in foci of zoonotic cutaneous leishmaniasis in Turkmenistan].
    Author: Strelkova MV, Eliseev LN, Ponirovskiĭ EN, Erokhin PI, Rakitskaia TA, Valevich TA, Sysoev VV, Allenov VA, Adamishina TA, Dergacheva TI.
    Journal: Med Parazitol (Mosk); 1993; (5):34-7. PubMed ID: 8127269.
    Abstract:
    In 1991-1992, 230 isolates were obtained in the Tedzhen oasis and its adjacent desert areas: 172 isolates from great gerbils, 39 from P. papatasi, and 19 from human cutaneous leishmaniasis patients. All the isolates were identified by the isoenzyme polyacrylamide gel electrophoresis by 8 enzymes. The characteristics of Leishmania circulation in the hyperendemic foci of Turkmenistan were similar to those previously studied in the mesoendemic areas of Uzbekistan and Kazakhstan. L. turanica which is non-pathogenic for man prevailed among infected great gerbils in winter, spring, and early summer, making the natural foci epidemiologically safe in that period of time. It was only in August-September that the great gerbil infection rate by L. major appeared to increase, occasionally reaching 100%. Epizootics due to L. major are developing in the presence of L. turanica, therefore most isolates are clone mixtures of L. major and L. turanica. P. papatasi is the only vector in the Tedzhen oasis; there has been strong evidence for its transmission of both L. major and L. turanica, which makes the concept inconsistent that P. papatasi is associated only with L. major. The overall analysis of recent findings of the distribution of L. major in the populations of great gerbils makes it possible to limit the former endemic zoonotic cutaneous leishmaniasis areas to 40 degrees N latitude and the southern borders of Turkmenistan and Uzbekistan. Within this area, the distribution of L. major is uneven and associated basically with rivers, valleys, oases, and foothill desert plains.
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