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  • Title: [Metabolism of prostaglandins in the lungs of patients with various forms of tuberculosis].
    Author: Kaminskaia GO, Blonskaia GIu, Omarov TO, Lovacheva OV.
    Journal: Probl Tuberk; 1993; (4):8-10. PubMed ID: 8127850.
    Abstract:
    PgE and F2 alpha were measured and correlated with the use of radioimmunoassay in bronchoalveolar lavage from the affected and contralateral lungs of 86 tuberculous patients different by the disease form. PG concentrations were estimated per 1 mg of the protein. It is shown that a primary response to appearance of a tuberculous focus is a universal elevation of PgE levels in the whole respiratory area, definitely seen in new-onset cases. With the disease progress, the response is fading, and PgE is high in the inflammation site only. High PgF2 alpha is not specific for tuberculosis only and emerges by the focus in exudative inflammation and destruction. Excessive production of PgF2 alpha in the zone of the specific changes against inhibition of PgE synthesis throughout the respiratory organs participate in the formation of bronchial obstruction in patients with pulmonary tuberculosis.
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