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  • Title: Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8.
    Author: Yamada M, Monden T, Konaka S, Mori M.
    Journal: Somat Cell Mol Genet; 1993 Nov; 19(6):577-80. PubMed ID: 8128317.
    Abstract:
    The human gene encoding thyrotropin-releasing hormone receptor was assigned to chromosome 8, using human-Chinese hamster ovary somatic cell hybrids, analyzed by Southern hybridizations. Hybridization was carried out with a 32P-labeled fragment of the human TRH-R genomic DNA. Hybridization of this probe to a human specific 10.5-kb DNA fragment of EcoRI-digested WBC DNA was used to localize the human TRH-R gene. No hybridization, by contrast, was seen with this probe and hamster DNA after EcoRI treatment. Results from 18 somatic cell hybrids corroborated unequivocally that the human TRH-R gene can be assigned to human chromosome 8.
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