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  • Title: Modulation of the phenotype and function of bovine afferent lymph cells during infection with Trypanosoma congolense.
    Author: Flynn JN, McKeever DJ, Sileghem M, Naessens J.
    Journal: Vet Immunol Immunopathol; 1994 Jan; 40(1):17-29. PubMed ID: 8128607.
    Abstract:
    Alterations in the phenotype and function of cells isolated from bovine afferent lymph were studied following tsetse-transmitted Trypanosoma congolense infection. Little alteration was observed in the output of the CD2+ T cells in the lymph, and within this population the CD4:CD8 ratio remained relatively constant. By contrast, a marked decrease was observed in the output of gamma delta T cells over the first 7 days following infection. The number of B cells increased between 2 and 6 days post-infection, and thereafter returned to pre-infection values. Little change was observed within the afferent lymph veiled cell population. Examination of activation markers on the lymphocyte fraction of afferent lymph revealed a decrease in the number of cells expressing the Interleukin-2 receptor alpha-chain from Day 5 post-infection. At this time the expression of ACT 1, another early activation marker, was seen to increase. Afferent lymph cells collected pre-infection and on the first 4 days post-infection proliferated in response to stimulation with Concanavalin A in vitro. This response to mitogenic stimulation was completely abrogated from day five post-infection. However, these cells were not capable of suppressing the capacity of normal peripheral blood mononuclear cells to respond to mitogenic stimulus in co-culture assays. These studies suggest that although a degree of lymphocyte activation occurs in the afferent lymph following tsetse-transmitted infection with T. congolense, this may be sub-optimal owing to the immunosuppression which appears to operate at the level of the skin and the lymph nodes.
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