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  • Title: Synthesis and in vitro evaluation of 8-hydroxyquinoline analogs as inhibitors of dental plaque.
    Author: Warner VD, Sane JN, Mirth DB, Turesky SS, Soloway B.
    Journal: J Med Chem; 1976 Jan; 19(1):167-9. PubMed ID: 812992.
    Abstract:
    A group of 5-substituted 8-hydroxyquinolines with predicted log P values in the 1-4 range has been prepared from either 8-hydroxyquinoline or its appropriate derivative. 5-Formyl-, 5-iodo-, 5-fluoro-, 5-acetyl-, and 5-methoxymethyl-8-hydroxyquinoline in addition to methyl-5(8-hydroxyquinolyl)acetate and ethyl 5-(8-hydroxyquinolyl)acetate displayed greater in vitro antiplaque activity than 8-hydroxyquinoline.
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