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  • Title: A liquid chromatographic method for the determination of fenoprofen in equine plasma and urine.
    Author: Delbeke FT, Debackere M.
    Journal: Biomed Chromatogr; 1994; 8(1):29-31. PubMed ID: 8130630.
    Abstract:
    A high performance liquid chromatographic method to measure plasma and urine fenoprofen levels in equine biofluids is described. Liquid-liquid extraction with diethylether was used to isolate the drug from plasma and urine. The accuracy and reproducibility of the method were within acceptable limits over the concentration range 0-10 micrograms/mL and 0-20 micrograms/mL respectively from plasma and urine. Detection limits were 0.05 microgram/mL (2 mL plasma) and 0.2 microgram/mL (0.5 mL urine). This procedure was applied to ascertain the pharmacokinetics of a 3 g dose of fenoprofen calcium in a horse.
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