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  • Title: Human complement component C8. Molecular basis of the beta-chain polymorphism.
    Author: Dewald G, Hemmer S, Nöthen MM.
    Journal: FEBS Lett; 1994 Mar 07; 340(3):211-5. PubMed ID: 8131848.
    Abstract:
    The beta-chain of human complement component C8 exhibits a structural genetic polymorphism: using isoelectric focusing two major allotypes can be identified (C8B B ('basic') and C8B A ('acidic')). In the present report we describe a sequence polymorphism of the C8B gene (codon 63: AGA-->GGA) and demonstrate that the resulting amino acid substitution (Arg-->Gly) consistently differentiates between the two common charge variants of the C8 beta chain; the C8B B allotype is characterized by an Arg and the C8B A allotype by a Gly residue in position 63 of the C8 beta polypeptide chain.
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