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  • Title: T cell receptor V beta 15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines.
    Author: Smith LR, Kono DH, Asthana D, Balderas RS, Fujii Y, Lindstrom J, Theofilopoulos AN.
    Journal: J Immunol; 1994 Mar 01; 152(5):2596-600. PubMed ID: 8133067.
    Abstract:
    Ten Lewis rat T cell lines responsive to Torpedo californica acetylcholine receptor (AChR) were assayed for TCR V beta usage. All lines were CD4+, OX-22-, and exhibited reactivity to one or more AChR chains. Several different V beta s were expressed by these lines, but V beta 15 was dominant in 5 of 10 lines. Unique CDR3 sequences were observed among the 10 lines, although three of the V beta 15 rearrangements used J beta 1.4. These data suggest that V beta 15+ T cells are selected in the in vitro response to the antigenically complex AChR in the Lewis rat.
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