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  • Title: Cefadroxil concentrations in human serum, gingiva, and mandibular bone following a single oral administration.
    Author: Akimoto Y, Komiya M, Kaneko K, Fujii A.
    Journal: J Oral Maxillofac Surg; 1994 Apr; 52(4):397-400; discussion 400-1. PubMed ID: 8133373.
    Abstract:
    Cefadroxil concentrations in human serum, gingiva, and mandibular bone were measured by a paper disk method following a single 500-mg oral dose. The mean peak concentrations in serum, gingiva, and mandibular bone occurred at the identical time, 3 hours, and were 12.92 micrograms/mL, 6.50 micrograms/g, and 2.67 micrograms/g, respectively. Mean cefadroxil concentration ratios of gingiva/serum and mandibular bone/serum at the peak time were 0.54 and 0.21, respectively. Mean concentrations in gingiva and mandibular bone at the peak time exceeded the minimum inhibitory concentrations for 90% of clinically isolated strains of a alpha-hemolytic streptococci.
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