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  • Title: [The effect of a long-term administration of fluorine with food on the carcinogenesis and biochemical changes in the liver of rats].
    Author: Gorban' GP, Pliss MB, Karpilovskaia ED, Petrin' AS, Svatkov VI, Rubenchik BL.
    Journal: Vopr Pitan; 1975; (6):21-4. PubMed ID: 813384.
    Abstract:
    The effect of different amounts of fluorine in the ingested food (1.5 and 5 mg per 1 kg of body weight) on the development of tumours and biochemical changes in the liver of rats with carcinogenesis caused by their feeding on DAB was studied. With a long-term administration of fluorine in a dose of 1.5 mg/kg the appearance of macroscopically visible tumours in the liver proved less notable than with a lower dose or complete absence of fluorine. With carcinogenesis the rate of glycolysis in the liver of rats increases. A relationship between the inhibiting action of sodium fluoride on the glycolysis and changed activity of phosphofructokinase has been ascertained.
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