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  • Title: [The effect of new ACTH fragments on the behaviors of self-stimulation, avoidance and grooming in rabbits].
    Author: Burchuladze RA, Chabak R, Chippens GI.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1993; 43(6):1143-8. PubMed ID: 8135056.
    Abstract:
    We studied the influence of new cyclic analogues of ACTH fragments EHFRWGKPVG-NH2 and KHFRVG-NH2 on self-stimulation (SS) and active avoidance (AA) behaviour. Intraventricular injection of EHFRWGKPVG-NH2 in low doses (0.5-2.5 mcg) was shown to increase, that in higher doses (4-5 mcg) to decrease SS frequency. Injection of KHFRWG-NH2 in doses of 0.1-5 mcg resulted in 25-30% decrease of SS frequency during the first 15 min, its subsequent return to the background level and repeated decrease. In 24-48 h SS was 5-8% higher than the background level and practically was unchanged in the course of 2 h of experiment. When testing AA behaviour EHFRWGKPVG-NH2 in doses of 0.5-2 mcg induced twice shorter "anxiety time" and longer latency of AA. Both fragments (0.1-5 mcg) evoked excessive grooming. These effects persisted for 24-72 h. The role of the cyclic analogues of ACTH fragments in the mechanisms of positive and negative reinforcement is discussed.
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