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  • Title: Association study of schizophrenia with dopamine D3 receptor gene polymorphisms: probable effects of family history of schizophrenia?
    Author: Nimgaonkar VL, Zhang XR, Caldwell JG, Ganguli R, Chakravarti A.
    Journal: Am J Med Genet; 1993 Dec 15; 48(4):214-7. PubMed ID: 8135304.
    Abstract:
    Using a case-control design, a reported association of schizophrenia with homozygosity at the dopamine D3 receptor gene locus was investigated in a group of patients (n = 53), with schizophrenia (DSM-III-R), and psychiatrically normal controls (n = 61), matched for ethnicity and area of residence. No significant differences in the distribution of alleles or genotypes between the two groups could be detected. However, among patients with a family history of schizophrenia, as compared to controls without such family history, an association with allele 1 at this locus was noted (Odds ratio 12.4, C.I. 1.61, 96.35).
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