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  • Title: p53 protein expression in mammary and extramammary Paget's disease.
    Author: Kanitakis J, Thivolet J, Claudy A.
    Journal: Anticancer Res; 1993; 13(6B):2429-33. PubMed ID: 8135479.
    Abstract:
    p53 is a tumour-suppressor gene, mutations of which are found in malignant skin lesions. We studied the immunohistochemical expression of the (mutated) p53 protein in 17 cases of Paget's disease (12 mammary and 5 extramammary). Four of the mammary specimens (33.3%) expressed p53 within Paget's cells; in one of these an underlying ductal adenocarcinoma was present and this was also p53-positive. All extramammary cases proved p53-negative. These results underline the differences that exist between mammary and extramammary Paget's disease and favour the origin of the former from the underlying adenocarcinoma rather than the surface epithelium.
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