These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis of 9,10-anthraquinone monoalkylaminoalkylhydrazones as potential antitumor drugs.
    Author: Antonini I, Polucci P, Cola D, Palmieri G, Martelli S, Bontemps-Gracz M.
    Journal: Farmaco; 1993 Dec; 48(12):1641-8. PubMed ID: 8135988.
    Abstract:
    In the constant search for new compounds endowed with antitumor activity we have synthesized a series of anthraquinone hydrazones, which can bee seen either as opened-cycle modified anthrapyrazoles or as chromophore-modified anthracenediones. Seven 9,10-anthraquinone monoalkylaminoalkylhydrazones (3c-i) were synthesized from 10,10-dibromoanthrone (4) and a suitable N-alkylhydrazine. The hydrazones were converted into hydrochlorides and tested for their cytotoxic activity against L1210 murine leukemia cells. Two of them possess marginal activity in vitro.
    [Abstract] [Full Text] [Related] [New Search]