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  • Title: Murine hybridomas secreting monoclonal antibodies reacting with Mlsa antigens.
    Author: Di Giorgi L, De Matos C, Ellis BA, Matossian-Rogers A.
    Journal: Exp Clin Immunogenet; 1993; 10(4):219-23. PubMed ID: 8136179.
    Abstract:
    Murine monoclonal antibodies have been developed from spleens of AKR mice hyperimmunised with the monoclonal antibody against TCR-V beta 6. Two new monoclonal antibodies called AL-12-3 and AL-32-7 were able to specifically block Mlsa-induced but not MHC-induced mixed lymphocyte responses in a dose-dependent manner. Both antibodies are mouse IgG3 lambda chain isotype and bind to Mlsa-bearing lymphocytes from different strains of mice. The availability of such antibodies may well facilitate future research aimed at immunochemical and molecular characterization of Mls determinants.
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