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  • Title: Cellular and subcellular alterations of the thyroid gland in rats caused by lithium carbonate.
    Author: Valle FC, Hayashi H, Prates JC, Didio LJ.
    Journal: Bull Assoc Anat (Nancy); 1993 Jun; 77(237):39-43. PubMed ID: 8136532.
    Abstract:
    Biochemical, hematologic, histometric, structural and ultrastructural changes were studied in the thyroid gland of rats, whom were administered Lithium carbonate. It was noted that (1) the Li carbonate had a cumulative effect on the serum; (2) T3 and T4 hormones in the blood decreased throughout the experiment; (3) the red blood cells, hemoglobin, hematocrit, platelets and leukocytes decreased gradually; (4) the diameter of the thyroid follicles, the size of the follicular cells and colloid droplets decreased, whereas the stroma was invaded by a greater number of collagen fibers and blood capillaries.
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