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  • Title: On the mechanism of action of quinolone drugs.
    Author: Palumbo M, Gatto B, Zagotto G, Palù G.
    Journal: Trends Microbiol; 1993 Sep; 1(6):232-5. PubMed ID: 8137121.
    Abstract:
    Antibacterial quinolones are thought to inhibit DNA gyrase by trapping the enzyme as a complex with the DNA substrate. The precise molecular details of drug-DNA and drug-enzyme interactions remain controversial. Here, a model is proposed that accounts for the influence of magnesium ions on quinolone-DNA binding.
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