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  • Title: Carboplatin, epirubicin, and VP-16 chemotherapy in the treatment of small cell lung cancer.
    Author: Gridelli C, Ianniello GP, Maiorino A, Curcio C, D'Aprile M, Brancaccio L, Palmeri S, Gentile M, Comella G, Pedicini T.
    Journal: Am J Clin Oncol; 1994 Apr; 17(2):160-2. PubMed ID: 8141108.
    Abstract:
    In our study, 72 SCLC patients, 23 with limited and 49 with extensive disease, were treated with carboplatin, epirubicin, and VP-16 (CEV) chemotherapy (CBDCA 300 mg/m2 day 1, EDX 50 mg/m2 day 1, VP-16 100 mg/m2 i.v. days 1-3, every 4 weeks). Patients with limited disease were also subjected to concurrent "split-course" chest radiotherapy followed by surgery in responders if they were not staged IIIB at diagnosis. In limited disease we obtained 96.5% objective responses (OR) with 52.5% complete responses (CR), a median survival of 14 months, with 13% long-term survivors at 30 months. In extensive disease we obtained 83.6% OR with 28.5% CR, and a median survival of 10 months. Toxicity consisted mainly of manageable myelosuppression, especially for limited disease. These data show high activity of CEV chemotherapeutic regimen.
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