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  • Title: A defect in catecholamine neurons in patients with prolactin-secreting pituitary adenoma.
    Author: Van Loon GR.
    Journal: Lancet; 1978 Oct 21; 2(8095):868-71. PubMed ID: 81414.
    Abstract:
    Although basal plasma concentrations of dopamine, noradrenaline, and adrenaline in patients with prolactin-secreting pituitary adenoma are normal, responses to oral bromocriptine are not. 1 and 2 h after bromocriptine, plasma concentrations of these three catecholamines are decreased in normal men but not in patients with hyperprolactinaemia secondary to prolactin-secreting pituitary adenoma or in normoprolactinaemic patients in whom a pituitary adenoma has been removed. Patients with prolactin-secreting pituitary adenoma probably have a defect in the regulation of brain catecholamine metabolism.
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