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  • Title: Effect of intracisternal phentolamine on cerebral blood flow after subarachnoid injection of blood.
    Author: Martins AN, Newby N, Doyle TF, Kobrine AI, Ramirez A.
    Journal: J Neurosurg; 1976 Mar; 44(3):353-8. PubMed ID: 814210.
    Abstract:
    The hydrogen clearance method was used to measure total and focal cerebral blood flow (CBF) in the monkey before and for 5 hours after a simulated subarachnoid hemorrhage (SAH). Some monkeys also received 0.2 to 1.0 mg/kg phentolamine intracisternally 3 hours after SAH. Results show that SAH did not change cerebrovascular resistance, but as cerebral perfusion pressure decreased, CBF fell transiently. Phentolamine injected intracisternally 3 hours after SAH produced a significant fall in arterial blood pressure; cerebrovascular resistance did not change but CBF decreased significantly. These data indicate that intracisternal phentolamine cannot be considered potentially useful to treat ischemic encephalopathy after SAH.
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