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  • Title: Intravenous pulse cyclophosphamide--a new regime for steroid-resistant minimal change nephrotic syndrome.
    Author: Elhence R, Gulati S, Kher V, Gupta A, Sharma RK.
    Journal: Pediatr Nephrol; 1994 Feb; 8(1):1-3. PubMed ID: 8142205.
    Abstract:
    The treatment of steroid-resistant minimal change nephrotic syndrome (MCNS) continues to pose a therapeutic challenge. We conducted a randomised prospective controlled trial to evaluate the efficacy of i.v. cyclophosphamide compared with oral cyclophosphamide in 13 children with biopsy-proven steroid-resistant MCNS. All 7 patients receiving i.v. cyclophosphamide achieved remission; this was sustained in 4 patients, while 3 relapsed. However, even these 3 patients subsequently became steroid sensitive. Of the 6 patients who received oral cyclophosphamide, 2 dropped out, 1 responded and 3 children continued to remain steroid resistant. The children who received IV cyclophosphamide had more sustained remissions, longer periods without proteinuria and fewer significant side effects; this was achieved at a lower cumulative dose.
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