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  • Title: Prompt remission of post-renal transplant nephrotic syndrome with high-dose cyclosporine.
    Author: Srivastava RN, Kalia A, Travis LB, Diven SC, Gugliuzza KK, Rajaraman S.
    Journal: Pediatr Nephrol; 1994 Feb; 8(1):94-5. PubMed ID: 8142240.
    Abstract:
    A 2.8-year-old girl with focal segmental glomerulosclerosis had recurrence of nephrotic syndrome within 3 days of renal transplantation and the serum creatinine increased. Renal biopsy showed cellular rejection and also complete effacement of the epithelial cell foot processes. The rejection responded to methylprednisolone therapy but massive proteinuria persisted. An increase in the dose of cyclosporine A to 14 mg/kg per day was followed by immediate remission of the proteinuria. One month later, a second renal biopsy showed only focal fusion of foot processes. She remains free of proteinuria 2 years later. We propose that the higher dose of cyclosporine caused remission of the nephrotic syndrome.
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