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  • Title: [Urine levels of soluble interleukin 2 receptor and free light chain immunoglobulins in lupus nephritis].
    Author: Ling SH.
    Journal: Zhonghua Yi Xue Za Zhi; 1993 Dec; 73(12):756-8, 774. PubMed ID: 8143195.
    Abstract:
    To find out the relationship between soluble interleukin 2 receptor (sIL-2R) or free light chain immunoglobulins (FLCI) and the activity of lupus nephritis (LN), we determined sIL-2R by ELISA and FLCI by immunodiffusion in the urine of 30 patients with LN and 20 normal persons. We also studied the correlation of sIL-2R levels with clinical and serologic findings over 3 months in the patients. sIL-2R was significantly higher in the active LN patients (160 +/- 108U/ml) than in the normal controls (85 +/- 19U/ml, P < 0.01) and in the inactive LN patients (92 +/- 23 U/ml, P < 0.05), but their serum complements did not change significantly. The positive rate of urine FLCI was higher in the active LN patients than in the inactive LN patients (77% to 15%, P < 0.01) and the normal controls (negative). These results suggest that the urine sIL-2R and FLCI are sensitive markers for disease activity in LN.
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