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  • Title: Demonstration of carbohydrate structures in malignant melanoma tyrosinase.
    Author: Herrmann WP, Uhlenbruck G.
    Journal: Klin Wochenschr; 1976 Jan 15; 54(2):95-6. PubMed ID: 814368.
    Abstract:
    Electrophoretic studies on malignant melanoma extracts before and after treatment with neuraminidase revealed that tyrosinase is a glycoprotein containing N-acetyl-neuraminic acid. Double diffusion tests using Concanavalin A and the lectin from Ricinus communis show that the carbohydrated chain of tyrosinase contains D-mannose as a sugar unit located within the carbohydrate chain. The terminal neuraminic acid groups are linked to D-galactose. The enzymatic activity of tyrosinase is not inhibited by Concanavalin A.
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