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  • Title: Redundant regulatory elements account for the developmental control of a ribosomal protein gene of Dictyostelium discoideum.
    Author: Ken R, Singleton CK.
    Journal: Differentiation; 1994 Jan; 55(2):97-103. PubMed ID: 8143933.
    Abstract:
    In Dictyostelium discoideum, ribosomal protein genes along with other growth specific genes appear to be coordinately regulated, primarily in response to differences in the translational capacity of developing versus growing cells. In particular, expression of the members of this large class of genes is rapidly and dramatically deactivated when the developmental program is initiated and growth and division cease. In order to understand the mechanisms behind the deactivation event and how it is coupled to the transition from growth to development, we have analyzed the promoter of the V18 gene, a ribosomal protein gene characteristic of this class of growth specific genes. We have delineated three discrete regions involved in the transcription and regulation of the V18 gene. A initiator region which appears to function in a TATA-independent manner was required for transcription and for establishing start site utilization. Two regions upstream of this were defined, both of which were found to independently confer proper developmental regulation.
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